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Laboratory animals maintained in scientific centres in poland


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LABORATORY ANIMALS MAINTAINED

IN SCIENTIFIC CENTRES IN POLAND




Elżbieta Krysiak and Alina Czarnomska
ICLAS Reference Center for Biomedical Research in Immunology and Oncology

Department of Genetics and Laboratory Animal Breeding

The Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

Commission on Biology of Laboratory Animals Committee of Cellular and Molecular Pathology, Polish Academy of Sciences

The elaboration of this monograph was financially supported by the State Committee for Scientific Research, Warsaw


The technical assistance in elaboration and edition of this monograph was provided by the Medical Research Center, Polish Academy of Sciences (P.A.Sci.), Warsaw

LABORATORY ANIMALS MAINTAINED IN POLAND






Strain / stock / race


Origin (Institution, year)


Generation /breeding system


Hygienic status


Health control (methods)


Genetic control (methods)


General characteristic traits


Maintaining Center / Institution

/ Possibility of purchase

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2

3

4

5

6

7

8



MICE – INBRED STRAINS


129/Iiw

Memorial Sloan Kettering Cancer Center, USA, 1975

F98

b x s


CV

B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

129/SvW

Jax, USA, 1971

F66 + 16

Pedigreed breeding b x s



SPF


B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2b, Aw, Tyrp1, Tyr, Myo5a

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


AKR/W

The Netherlands Cancer Institute, Amsterdam, The Netherlands 1984

F65 + 18

Pedigreed breeding

b x s


SPF


B, P, W

AMS, RAPD, MM, MBI, MI

H-2k, a, Tyrp1, Tyrc, Myo5a, 60 – 80% of spontaneous lymphomas (females, males)

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


BALB/CanNCrlCmd

Charles River, Germany, 1997

F11

b x s


SPF

B, P, W, A




Mouse standard for most experiments, coat colour: A,b,c

Medical Research Center, Polish Academy of Sciences, Warszawa / yes

BALB/cIiw

Memorial Sloan Kettering Cancer Center, USA, 1975

F93

b x s


CV

B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

BALB/cJHanImp

ZFV Hannover, Germany, 1991

F42

b x s


CV-I

B, P, Mi

ACI, PS

Low incidence of spontaneous mammary gland tumors; the incidence of ovarian tumors, lung tumors, adrenal gland tumors; mice sensitive for radiation, with high blood pressure and susceptible for respiratory tract diseases; late maturing and long lasting fertility


Nofer Institute of Occupational Medicine, Łódź / yes

1


2

3

4

5

6

7

8

BALB/cKr

Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław, Poland, 1990

F64

b x s


CV

B, P, A, H

PN

Immunological research

Institute of Pediatrics Jagiellonian University Medical College, Kraków / yes excess

BALB/cKuoLod

Kuopio, Finland, 1992

F12

b x s


SPF

B, Mi, Bi, H, P, W

PS, ACI

Immunological, pharmaceutical, toxicological, oncological and feeding research

Polish Mother’s Memorial Hospital Research Institute, Łódź / yes

BALB/cPzh

Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław, Poland, 1980

F52

b x s


CV-I

B, P, Mi

MM, MI




National Institute of Hygiene, Warszawa / yes

BALB/cW

National Institute of Hygiene, Warszawa, Poland, 1986

F44 + 15

Pedigreed breeding

b x s

and Lane – Peter traffic light system



SPF

CV-I


B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2d, A, Tyrp1b, Tyrc, Myo5a, >40% of spontaneous lung tumors in females

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


BN/aW

Own inbred strain, Poland, 1961

F138

Pedigreed breeding

b x s


CV-I

B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2bp1, A, Tyrp1, Tyrc, Myo5a, low incidence of tumors

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


C3H/HeHanImp

ZFV Hannover, Germany, 1991

F43

b x s


CV-I

B, P, Mi

ACI, PS

Mammary gland tumors in 90% of females, sensitive for chloroform – necrosis of seminiferous tubulles

Nofer Institute of Occupational Medicine, Łódź / yes

C3H/HeJCrl

Charles River, Germany, 1999

F4

b x s


SPF

B, Mi, Bi, H, P, W

ACI, PS

Immunological and oncological research

Polish Mother’s Memorial Hospital Research Institute, Łódź / yes

C3H/Iiw

Charles River Breeding Laboratories, 1976

F95

b x s


CV

B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

C3H/Kr

Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław, Poland, 1990

F90

b x s


CV

B, P, A, H

PN

Immunological research

Institute of Pediatrics Jagiellonian University Medical College, Kraków / yes excess

C3H/W

Institute of Oncology, Budapest, Hungary, 1955

F133 + 16

pedigreed breeding

b x s

and Lane – Peter traffic light system




SPF

CV-I


B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2k, A, Tyrp1, Tyr, Myo5a, 80% of spontaneous mammary gland tumors in females

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


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2

3

4

5

6

7

8

C57BL/10Tar

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland, 1987

F30

Pedigreed breeding

b x s


CV







H-2b, a, Tyrp1, Tyr, Myo5a, used for F1 crossing with CBA mice

Warsaw University, Faculty of Biology, Warszawa / yes, free of charge

C57Bl/10Tar

Warsaw University, Faculty of Biology, Warszawa, Poland

F6

b x s


CV

A




For research on neurodegeneration eg. Parkinson disease

Laboratory for Experimental Animals, The Medical University of Warsaw, Warszawa /yes limited number

C57BL/10W

The Netherlands Cancer Institute, Amsterdam, The Netherlands, 1988

F33 + 12

pedigreed breeding

b x s

and Lane – Peter traffic light system



SPF

CV-I


B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2b, a, Tyrp1, Tyr, Myo5a, susceptible for radiation induced lymphoma

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes


C57BL/6Iiw

Memorial Sloan Kettering Cancer Center, USA, 1975

F97

b x s


CV

B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

C57Bl/6J

Jackson Laboratory, USA, 2000

F5

b x s


SPF

B, W, P, A




Control for knock-out mice

Medical Research Center, Polish Academy of Sciences, Warszawa / yes

C57BL/6JHanImp

ZFV Hannover, Germany, 1991

F39

b x s


CV-I

B, P, Mi

ACI, PS

Low incidence of mammary gland tumors, resistant for cancerogenes, susceptible for radiation induced leukemia and lymphoma (90%)

Nofer Institute of Occupational Medicine, Łódź / yes

C57BL/6W

Jax, USA, 1998

F10

pedigreed breeding

b x s


SPF

B, P, W, A

AMS,

H-2b, a, Tyrp1, Tyr, Myo5a, susceptible for radiation induced lymphoma

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes

C57BL/Kr

Jagiellonian University, Dept. of Genetics and Evolution, Kraków, Poland, 1998

F47

b x s


CV

B, P, A, H

PN

Immunological research

Institute of Pediatrics Jagiellonian University Medical College, Kraków / yes excess

C57BL/Kw

Jagiellonian University, Dept. of Genetics and Evolution, Kraków, Poland

F92

b x s


CV

P

MBI, AMS

aaBBCCDD

Jagiellonian University, Dept. of Genetics and Evolution, Kraków / yes, free of charge

CBA/Iiw

Department of Surgery University of Edinburgh, Medical School, Great Britain, 1977

F96

b x s


CV

B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

CBA/Kr

Jagiellonian University, Dept. of Genetics and Evolution, Kraków, Poland, 1988

F60

b x s


CV

B, P, A, H




High incidence of spontaneous lung and intestinal tumors

Institute of Pediatrics Jagiellonian University Medical College, Kraków / yes excess

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2

3

4

5

6

7

8

CBA/Kw

Jagiellonian University, Dept. of Genetics and Evolution, Kraków, Poland



F 121

b x s


CV

P

MBI, AMS

AABBCCDD

Jagiellonian University, Dept. of Genetics and Evolution, Kraków / yes free of charge

CBA/Tar

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland, 1987

F32

pedigreed breeding

b x s


CV







H-2k, A, Tyrp1, Tyr, Myo5a, used for F1 crossing with C57BL/10 mice

Warsaw University, Faculty of Biology, Warszawa / yes, free of charge

CBA/W

Radiobiol.Unit, Harwell, 1964 to Tar, 1975 to Institute of Oncology, Warszawa, Poland

F62 + 2

pedigreed breeding

b x s


SPF

B, P, W, A

AMS, RAPD, MM, MBI, MI

H-2k, A, Tyrp1, Tyr, Myo5a, spontaneous liver tumors in 50%

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes

CFW/Pzh

The Nencki Institute of Experimental Biology Polish Academy of Sciences, Łomna, Poland, 1969

F93

b x s


CV-I

B, P, Mi

MM, MI

Mice sensitive for antibiotics of tetracyclin group

National Institute of Hygiene, Warszawa / yes

DBA/2Kr

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland, 1990

F72

b x s


CV

B, P, A, H




Oncological research (leukemias)

Institute of Pediatrics Jagiellonian University Medical College, Kraków / yes excess

DBA/2Iiw

Charles River Breeding Laboratories, 1976

F77

b x s


CV



B, P, Mi

KM, PN




Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wrocław / yes

DBA/2W

Jax, USA, 1999

F10

pedigreed breeding

b x s


SPF

B, P, W, A

AMS, RAPD

H-2d, a, Tyrp1b, Tyr, Myo5ad

Maria Skłodowska – Curie Memorial Cancer Center and Institute of Oncology, Warszawa / yes

FVB/TacCmd

Brigham and Women Hospital, Harvard University, Boston prof. E. Neer, USA, 1999

F7

b x s


SPF

B, W, P, A




Control for mice with protein G alpha q transgene, source of eggs for production of transgenic animals

Medical Research Center, Polish Academy of Sciences, Warszawa / yes

KE/Kw

Jagiellonian University, Department of Genetics, Kraków, Poland, 1952

F134

b x s


CV

P

MBI, AMS

aabbccPP

Jagiellonian University, Dept. of Genetics and Evolution / yes, free of charge

KP/Kw

Jagiellonian University, Department of Genetics, Kraków, Poland, 1952


F 133

b x s


CV

P

MBI, AMS

aabbCCpp

Jagiellonian University, Dept. of Genetics and Evolution / yes, free of charge

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2

3

4

5

6

7

8

LT/SvTar

Cell Differentiation Laboratory, University of Geneva, Swiss, 1988

F22

pedigreed breeding

b x s


CV







A, Tyrp1btl, Tyr, high incidence of ovarian tumors

Warsaw University, Faculty of Biology, Warszawa / yes, free of charge

NMRI/Uwm

Göttingen, Germany, 1974

b x s

CV

Veterinary control







University of Warmia and Mazury, The Faculty of Veterinary Medicine, Olsztyn / yes excess


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